2006 Heart-Brain summit proceedings

Sudden unexplained death in epilepsy: The role of the heart

Stephan U. Schuele, MD

Department of Neurology
Cleveland Clinic, Cleveland, OH
Northwestern University,
Chicago, IL

 

Peter Widdess-Walsh, MD

Department of Neurology
Cleveland Clinic
Cleveland, OH

 

Adriana Bermeo, MD

Department of Neurology
Cleveland Clinic
Cleveland, OH

 

Hans O. Lüder, MD, PhD

Chairman, Department of Neurology
Cleveland Clinic
Cleveland, OH
ludersh@ccf.org

ARTICLE INTRODUCTION

Sudden unexplained death in epilepsy (SUDEP) is defined as the sudden, unexpected death of an otherwise healthy person with epilepsy without apparent cause. Death occurs during normal activities and under benign circumstances; it does not arise from trauma, aspiration, or intractable status epilepticus.

SUDEP is most commonly attributed to one of three mechanisms: seizure-induced central apnea, cardiac arrhythmia, and neurogenic pulmonary edema. This review will focus on the potential cardiac causes of SUDEP after providing a brief overview of SUDEP and its other proposed mechanisms.

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